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| mRNA | tRNA |
| Linear structure | Cloverleaf shape |
| In mammals, mRNAs are 300 to 12000 nucleotides long | 76 to 90 nucleotides |
| Site of synthesis is the nucleus | Produced in the cytoplasm |
| They provide a template or carry genetic information contained in DNA for protein synthesis | They carry specific amino acids to ribosomes for protein synthesis |
| mRNA carries codons for the translation process | They carry anticodons, specific to particular amino acid |
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