What is the reason for inflammation …
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Meghna Thapar 4 years, 3 months ago
Histamine is not only released when the body encounters a toxic substance, it is also released when mast cells detect injury. It causes nearby blood vessels to dilate allowing more blood to reach the site of the injury or infection. The Fc region of immunoglobulin E (IgE) becomes bound to mast cells and basophils and when IgE's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators. These similarities have led many to speculate that mast cells are basophils that have "homed in" on tissues. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. ... Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
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