Human blood group related to genetics …
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Posted by Riti Malhotra 8 years, 10 months ago
- 2 answers
Payal Singh 8 years, 10 months ago
Ans. Blood groups are inherited from our parents in the same way as other genetic traits (eg, eye colour).
ABO and Rhesus are the most well-known among the blood group systems.
The ABO blood group system is determined by the ABO gene, which is found on chromosome 9. The four ABO blood groups, A, B, AB and O, arise from inheriting one or more of the alternative forms of this gene (or alleles) namely A, B or O.
Genetic Combinations of ABO Blood Groups :
| Blood Group | Possible Genes |
| A | AA or AO |
| B | BB or BO |
| AB | AB |
| O | OO |
The A and B alleles are codominant so both A and B antigens will be expressed on the red cells whenever either allele is present. O alleles do not produce either A or B antigens, thus, are sometimes called ‘silent' alle.
ABO Inheritance Patterns :
| Parent Blood Group | Child's Blood Group |
| O and O | O |
| O and A | O or A |
| O and B | O or B |
| O and AB | A or B |
| A and A | A or O |
| A and B | O or A or B or AB |
| A and AB | A or B or AB |
| B and B | B or O |
| B and AB | A or B or AB |
| AB and AB | A or B or AB |
The Rh Blood group System is attributable to two genes, RHD and RHCE, which are located on chromosome 1.
Rh positivity or Rh negativity is distinguished by testing for the RhD antigen, the expression of which depends upon whether an RHD gene has been inherited from one or both parents.
The RHD gene is dominant so a person is considered to be RhD positive whenever this gene is present, even though the gene may have only been inherited from one parent. Conversely, a person will be RhD negative if no RHD gene is inherited.
| Parental Rh Type | Child's Rh Type |
| Positive and Positive | Positive or Negative |
| Positive and Negative | Positive or Negative |
| Negative and Negative | Negative |
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Naveen Sharma 8 years, 10 months ago
Blood groups are inherited from our biological parents in the same way as eye colour and other genetic traits.
Ans. Within the ABO Blood Group system, the A and B genes are co-dominant, i.e. these will be expressed whenever the gene is present. The O gene is silent and only expressed when neither A nor B is present.
The Rh(D) group is also dominant and will be expressed if inherited from either parent. If the Rh(D) gene is not inherited from either biological parent then the individual will be Rh(D) negative.
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