How do micro organisms enter in …

Organ Specific Manifestation- These are the diseases caused in the same organ or organ system as the point of entry of the microbe. E.g. Tuberculosis which enters through the nose and affects the lungs. (Both are organs of the respiratory system)

Tissue Specific Manifestation- These are the diseases caused in a different organ at the point of entry. E.g. Japanese Encephalitis which enters through the blood but affects the brain.

An infection like HIV comes into the body via the sexual organs, will spread to lymph nodes all over the body. Malaria-causing microbes, entering through a mosquito bite, will go to the liver, and then to the red blood cells. The virus causing Japanese encephalitis, or brain fever, will similarly enter through a mosquito bite. But it goes on to infect the brain.