Why lysines and Arginines are found …
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Meghna Thapar 5 years, 5 months ago
Histones are primarily made up of the amino acids Lysine and Arginine. These amino acids that make up the histones (arginine and lysine) have a positive charge due to the nitrogen group of their chemistry. DNA is able to bind to the histones because DNA has a negative charge due to their phosphates. Histones contain a large proportion of the positively charged (basic) amino acids, lysine and arginine in their structure. DNA is negatively charged due to the phosphate groups on its backbone. These result of these opposite charges is a strong attraction and therefore high binding affinity between histones and DNA.
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