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State chagaff base complementarity rule

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State chagaff base complementarity rule
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Meghna Thapar 5 years ago

Chargaff's rule states that DNA from any cell of any organism has a 1:1 ratio of pyrimidine and purine bases and, more specifically, that the amount of guanine, a purine base, is equal to cytosine, a pyrimidine base; and the amount of adenine, a purine base, is equal to thymine, a pyrimidine base.

The rules of base pairing (or nucleotide pairing) are:

  • A with T: the purine adenine (A) always pairs with. the pyrimidine thymine (T)
  • C with G: the pyrimidine cytosine (C) always pairs with. the purine guanine (G)
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