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How replication occurs in lagging strand??

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How replication occurs in lagging strand??
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Sangitaben Patel 6 years, 11 months ago

In leading strand there occurs no problem with the replication as polymerisation occurs in the direction of replication fork. But in lagging stand, the direction of polymerisation is opposite to the direction of replication fork and DNA cant polymerise continuosly as DNA doesnt show denovo synthesis, RNA primer has to come repeatedly to form 10-15 nucleotides as a starting material to DNA. DNA then forms some nucleotides from this starting material and then after forming some nucleotides it stops. Then again RNA primer comes and form 10-15 nucleotides....this process continues. The small segments of nucleotides formed by DNA are called okazaki segments. They are joined by DNA ligase after the polymerisation is completed.
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