How is clotting done by platelets?

Platelets also interact with other blood proteins to form fibrin. Fibrin strands form a net that entraps more platelets and blood cells, producing a clot that plugs the break. Formation of a clot also involves activation of a sequence of blood clotting factors that generate thrombin.

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along ,in the blood is generally done using the Clauss method for fibrinogen testing.

On the surface of these activated platelets, many different clotting factors work together in a series of complex chemical reactions (known as the coagulation cascade) to form a fibrin clot. The clot acts like a mesh to stop the bleeding. Coagulation factors circulate in the blood in an inactive form.