What is aminoacylation? State it's significance.
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Amar Kumar 8 years, 3 months ago
Aminoacylation:It is a two stage process whereby amino acids are 'activated' in order to be incorporated into proteins; energy in the form of ATP is required and one of a family of 20 aminoacyl-tRNA synthetases, one specific for each amino acid, links the carboxyl group of the amino acid to either the 2′- or 3′-hydroxyl group of the ribose unit at the 3′-end of tRNA.
Amino acids are activated in the presence of ATP and linked to (cognate) t-RNA
Significance: Carries amino acid to the site of protein synthesis / reaches amino acids to the respective codon
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