Thalassaemia either produce excess alpha or …
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Thalassaemia either produce excess alpha or beta subunit of haemoglobin leading to impaired oxygen binding capacity.How would you determine which subunit is produced in excess and what type of thalassaemia the patient is suffering with: A or B?
Posted by Lokeswari Bosi 3 years, 8 months ago
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Meghna Thapar 3 years, 8 months ago
One form of nondeletion α-thalassemia, called Hb Constant Spring (HbCS), is particularly prevalent in southeast Asia. It is caused by a chain termination mutation, which results in the synthesis of an elongated α-globin subunit that accumulates at very low levels in RBCs of affected individuals. Mutations in the HBB gene cause beta thalassemia. The HBB gene provides instructions for making a protein called beta-globin. Beta-globin is a component (subunit) of hemoglobin. Hemoglobin consists of four protein subunits, typically two subunits of beta-globin and two subunits of another protein called alpha-globin.
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