Cause of hemophilia and thalassemia
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Swati Sohni 6 years, 9 months ago
Hi,
Haemophilia is a X-linked recessive genetic disorder that impairs the body’s ability to coagulate or clot blood when a blood vessel breaks.This disorder occurs when a single factor from the several factors required for the process of coagulation is affected. Hemophilia A is caused by a mutation in the gene for factor VIII, so there is deficiency of this clotting factor.Hemophilia B (also called Christmas disease) results from a deficiency of factor IX due to a mutation in the corresponding gene.It is a ***-linked recessive disorder inherited through the X-chromosome. The possibility of a male offspring inheriting this disorder is greater than in females
Thalassemia is an autosomal recessive disorder whcih affects the blood. Haemoglobin synthesised by the body is abnormal and is unable to carry oxygen efficiently. this later leads to the destruction of blood cells and thereby causes anemia.Thalassemia develops when there is some abnormality in any one of the genes that are involved in the production of hemoglobin and this defect can be inherited from your parents.
Thalassemia disease exists in two forms namely:
Alpha-thalassemia – At least one of the alpha globin genes has an abnormality or mutation.
Beta-thalassemia – The beta globin genes are infected.
Hope this will help you out ..!!
1Thank You